Gibson, K.Sharp, R.Ullman, A.Morris, S.Kleidon, T.Esterman, A.2025-12-182025-12-182021Journal of Perinatology, 2021; 41(10):2505-25120743-83461476-5543https://hdl.handle.net/11541.2/148087Objective: To determine the incidence of adverse events (AEs) associated with umbilical catheters in the neonatal population. Study design: Systematic review and meta-analysis of observational studies and randomized controlled trials published between 2010 and 2020. Results: In total 14,226 umbilical venous catheters (UVCs) and 4228 umbilical arterial catheters (UACs) were included. Overall, 13.4% of UVCs were associated with an AE (95% CI: 10.1-17.0) or 2.4 per 1000 catheter days (95% CI: 1.8-3.0). UACs had an AE rate of 9% (95% CI: 5.9-12.8) or 0.87 per 1000 catheter days (95% CI: 0.4-1.3). UVC malposition was the most common (41.7% [95% CI: 27.6-56.5]). Local injury from UAC taping was the most common AE in one study. Conclusions: Umbilical catheters have a high incidence of AEs. Research into accurate methods of tip verification, tip surveillance, and securement is required.enCopyright 2021 The Author(s), under exclusive licence to Springer Nature America Access Condition Notes: Accepted manuscript available after 1 April 2022adverse events (AEs)umbilical cathetersumbilical venous catheters (UVCs)umbilical arterial catheters (UACs)Journal article10.1038/s41372-021-01147-x2-s2.0-85110609686Sharp, R. [0000-0003-3334-2990]Esterman, A. [0000-0001-7324-9171]