Warrener, R.N.Russell, R.A.Margetic, D.2014-10-302014-10-301997Synlett: accounts and rapid communications in synthetic organic chemistry, 1997; 1997(1):38-400936-52141437-2096http://hdl.handle.net/2440/868085-Azabicyclo[2.2.0]hex-2-en-6-one 1 undergoes [2π+2π] cycloaddition with dimethyl acetylene dicarboxylate (Ru-catalysed) to yield aza[3]ladderane 2 which is transformed to aza[5]ladderanes 4 and 5 on treatment with cyclobutadiene and to azahomo[5]ladderanes 10 and 11 on reaction with cyclopentadiene. The specifities of these cycloaddition reactions are in agreement with predictions made using ab initio calculations. Chlorosulfonylisocyanate addition is used to access azahomo[4]ladderane 14.en© Georg Thieme Verlagcycloaddition-specifitiespolycyclobutaneschlorosulfonyl isocyanateab initio calculations5-azabicyclo[2.2.0]hex-2-en-6-oneThe synthesis of aza[n]ladderanes and azahomo[n]ladderanes containing β-lactams at the terminusThe synthesis of aza[n]ladderanes and azahomo[n]ladderanes containing beta-lactams at the terminusJournal article003000923310.1055/s-1997-697A1997WF585000102-s2.0-1542472920102296