Kwong, A.K.L.Eeles, A.L.Anderson, P.J.Badawi, N.Boyd, R.N.Cameron, K.L.Cheong, J.L.Y.Colditz, P.Koorts, P.Crowle, C.Dale, R.C.Doyle, L.W.Fahey, M.George, J.Hunt, R.W.McNamara, L.Morgan, C.Novak, I.Olsen, J.E.Reid, N.et al.2024-09-242024-09-242024Journal of Pediatrics, 2024; 268:113949-1-113949-70022-34761097-6833https://hdl.handle.net/2440/142526This article was accepted for publication on 19 April 2024.Objective To describe the implementation of the international guidelines for the early diagnosis of cerebral palsy (CP) and engagement in the screening process in an Australian cohort of infants with neonatal risk factors for CP. Study design Prospective cohort study of infants with neonatal risk factors recruited at <6 months corrected age from11 sites in the states of Victoria, New South Wales, and Queensland, Australia. First, we implemented a multimodal knowledge translation strategy including barrier identification, technology integration, and special interest groups. Screening was implemented as follows: infants with clinical indications for neuroimaging underwent magnetic resonance imaging and/or cranial ultrasound. The Prechtl General Movements Assessment (GMA) was recorded clinically or using an app (Baby Moves). Infants with absent or abnormal fidgety movements on GMA videos were offered further assessment using the Hammersmith Infant Neurological Examination (HINE). Infants with atypical findings on 2/3 assessments met criteria for high risk of CP. Results Of the 597 infants (56% male) recruited, 95% (n = 565) received neuroimaging, 90% (n = 537) had scorable GMA videos (2% unscorable/ 8% no video), and 25% (n = 149) HINE. Overall, 19% of the cohort (n = 114/597) met criteria for high risk of CP, 57% (340/597) had at least 2 normal assessments (of neuroimaging, GMA or HINE), and 24% (n = 143/597) had insufficient assessments. Conclusions Early CP screening was implemented across participating sites using a multimodal knowledge translation strategy. Although the COVID-19 pandemic affected recruitment rates, there was high engagement in the screening process. Reasons for engagement in early screening from parents and clinicians warrant further contextualization and investigation.enCrown Copyright © 2024 Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).cerebral palsyearly detectiongeneral movements assessmenthigh-risk infantHumansCerebral PalsyMagnetic Resonance ImagingNeurologic ExaminationNeonatal ScreeningEarly DiagnosisRisk FactorsCohort StudiesProspective StudiesInfantInfant, NewbornAustraliaFemaleMaleNeuroimagingCOVID-19Translational Research, BiomedicalJournal article10.1016/j.jpeds.2024.1139492024-09-23688235Anderson, P.J. [0000-0002-3730-4652]