Graf, S.W.Whittle, S.L.2015-03-152015-03-152014SpringerPlus, 2014; 3(1):698-1-698-42193-18012193-1801http://hdl.handle.net/2440/89843We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severity of this condition appears to correlate with duration of therapy. Isotretinoin is a well-established treatment for severe acne. It is important for the rheumatologist be aware of this phenomenon when assessing young patients with musculoskeletal symptoms and evidence of radiological abnormalities.en© 2014 Graf and Whittle; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Isotretinoin-induced skeletal hyperostosisJournal article003002434510.1186/2193-1801-3-6980003591194000032-s2.0-84930195907160981Whittle, S.L. [0000-0001-7417-7691]