Thai, Le Minh2010-04-062010-04-062007http://hdl.handle.net/2440/57334This thesis describes two studies, one in vitro and one in vivo, which show that Apo2L/TRAIL can prevent breast cancer-induced bone destruction, and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone. They also highlight the complexity of Apo2L/TRAIL signalling, and the need for further studies into this area to fully exploit the potential of Apo2L/TRAIL as an anti-cancer agent for breast and other cancers.breast cancer; metastasisThesis20100323154557