Theopold, Ulrich J.Li, DongmeiFabbri, MarcoScherfer, ChristophSchmidt, Otto2007-05-112007-05-112002Cellular and Molecular Life Sciences, 2002; 59(2):363-3721420-682Xhttp://hdl.handle.net/2440/27803The original publication can be found at www.springerlink.comIn contrast to both vertebrates and non-insect arthropods, little is known about the coagulation of hemolymph (hemostasis) in insects. We discuss the integration of the hemostatic response with other branches of the insect immune system. We also describe the present stage in the characterization of both soluble and cellular factors that contribute to hemostasis in insects. The factors of the well-characterized clotting cascades of vertebrates, CMLS, Cell. Mol. Life Sci. 59 (2002) 363–372 1420-682X/02/020363-10 $ 1.50 + 0.20/0 © Birkhäuser Verlag, Basel, 2002 CMLS Cellular and Molecular Life Sciences primitive chelicerates and crustaceans are used to assess the implications of sequencing the whole Drosophila genome for searching candidate genes involved in hemostasis. Some striking similarities between blood clotting in vertebrates and the reaction of insect cells involved in hemolymph coagulation have implications for a phylogenetic comparison of hemostasis between divergent animal classes.en© Birkhäuser Verlag, Basel, 2002Insect immunity; blood clotting; phosphatidylserine; phenoloxidase; coagulogen; transglutaminase; Drosophila melanogasterJournal article002002120010.1007/s00018-002-8428-40001741566000142-s2.0-0036183148