Fanning, K.J.Robertson, T.A.Prins, J.B.Roberts, M.S.2025-12-172025-12-172011Antimicrobial Agents and Chemotherapy, 2011; 55(6):3008-30110066-48041098-6596https://hdl.handle.net/1959.8/123640This work sought to define how pancreatitis affected antibiotic distribution in a perfused rat pancreas model. The distribution kinetics of four antibiotics were examined in control animals and animals with pancreatitis. Meropenem and piperacillin distributed into the extracellular space, and their distribution kinetics were unaffected by pancreatitis. In contrast, in pancreatic cells from animals with pancreatitis, ciprofloxacin showed a reduced uptake and clindamycin showed a reduced distribution.enCopyright 2011 American Society for Microbiologyantibiotic therapypancreatitisJournal article10.1128/AAC.00416-10000290713400078