Smedley, C.J.Giel, M.C.Molino, A.Barrow, A.S.Wilson, D.J.D.Moses, J.E.2022-12-132022-12-132018Chemical Communications, 2018; 54(47):6020-60231359-73451364-548Xhttps://hdl.handle.net/2440/137056We demonstrate 1,2-dibromoethane-1-sulfonyl fluoride (DESF) as a bench-stable and readily accessible precursor to the robust SuFEx connector, 1-bromoethene-1-sulfonyl fluoride (BESF). The in situ generation of BESF from DESF opens up several new reaction profiles, including application in the syntheses of unprecedented 3-substituted isoxazole-5-sulfonyl fluorides, 1-substituted-1H1,2,3-triazole-4-sulfonyl fluorides, 2-amino-1-bromoethane-1-sulfonyl fluorides and 4-bromo-b-sultams in good to excellent yields. These new modules comprise a pendant sulfonyl fluoride handle, which further undergoes facile and selective SuFEx reactions with a selection of aryl silyl ethers to generate stable and useful sulfonate connections.en© The Royal Society of Chemistry 2018Journal article10.1039/c8cc03400a2022-12-13628338Barrow, A.S. [0000-0003-3661-5173]