Immune response genes in the post-Q-fever fatigue syndrome, Q fever endocarditis and uncomplicated acute primary Q fever

Helbig, K.Harris, R.Ayres, J.Dunckley, H.Lloyd, A.Robson, J.Marmion, B.2006-12-032006-12-032005QJM: an international journal of medicine, 2005; 98(8):565-5741460-27251460-2393http://hdl.handle.net/2440/17146<h4>Background</h4>The influence of immune response gene variations on the development of chronic complications of Q fever is presently unclear.<h4>Aim</h4>To compare the frequencies of allelic polymorphisms in immune response genes in different Q fever patient groups.<h4>Design</h4>Genetic association study.<h4>Methods</h4>We measured the frequencies of immune response gene variants in: (i) an expanded group of 31 post-Q-fever fatigue patients (QFS); (ii) 22 Q fever endocarditis patients (QFE); and (iii) 22 patients who made an uncomplicated recovery from their initial attack of primary acute Q fever, comparing them with various standard control panels from the general population.<h4>Results</h4>There were significant differences between the three Q fever groups. QFS patients differed from both QFE and uncomplicated patients and controls in the frequency of carriage of HLA-DRB1*11 and of the 2/2 genotype of the interferon-gamma intron1 microsatellite. Carriage of the HLA DRB1*11 allele was associated with reduced interferon-gamma and IL-2 responses from PBMC stimulated with ligand in short-term culture. QFE showed differences in the IL-10 promoter microsatellites R and G and had higher frequencies of the TNF-alpha receptor II 196R polymorphism. Q fever patients who had made an uncomplicated recovery differed from those with QFS or QFE, but were not significantly different in allelic frequencies to the control panels.<h4>Discussion</h4>These immunogenetic differences support the concept of different immune states in chronic Q fever, determined by genetic variations in host immune responses, rather than by solely properties of Coxiella burnetii.enHumansCoxiella burnetiiEndocarditis, BacterialQ FeverFatigue Syndrome, ChronicReceptors, Tumor Necrosis Factor, Type IIGene FrequencyPolymorphism, GeneticInterferon-gammaGenetic VariationImmune response genes in the post-Q-fever fatigue syndrome, Q fever endocarditis and uncomplicated acute primary Q feverJournal article002005076710.1093/qjmed/hci0860002307256000032-s2.0-2644450375354815