Li, Y.Yang, G.Gerstweiler, L.Thang, S.H.H.Zhao, C.-X.2023-01-202023-01-202023Advanced Functional Materials, 2023; 33(7):2210387-1-2210387-311616-301X1616-3028https://hdl.handle.net/2440/137266Published online: December 7, 2022Stimuli-responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli-responsive peptides and proteins, their design principles and applications, including temperature-, pH-, light-, metal ion-, and enzyme-responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide- and protein-based materials and their diverse applications.en© 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.light; metal ions; peptides; pH; proteins; stimuli-responsive behavior; temperatureJournal article10.1002/adfm.2022103872023-01-20630176Yang, G. [0000-0002-6194-1918]Gerstweiler, L. [0000-0002-2421-5503]