McDevitt, C.Shintre, C.Grossmann, G.Pollock, N.Prince, S.Callaghan, R.Ford, R.2009-12-212009-12-212008FEBS Letters, 2008; 582(19):2950-29560014-57931873-3468http://hdl.handle.net/2440/54875P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.enMultidrug resistanceMembrane proteinProtein structureElectron crystallographySAXSABCB1Journal article002009348310.1016/j.febslet.2008.07.0220002591232000222-s2.0-4874910715136996McDevitt, C. [0000-0003-1596-4841]