Kanai-Azuma, MasamiMattick, John S.Kaibuchi, KozoWood, Stephen Andrew2007-05-112007-05-112000Mechanisms of Development, 2000; 91(1-2):383-3860925-4773http://hdl.handle.net/2440/28008The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053–1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina.enFAM; De-ubiquitinating enzyme; AF-6; Canoe; Ras-binding protein; Retinal pigment epithelium; Lens epithelium; Corneal epitheliumJournal article000100049510.1016/S0925-4773(99)00294-4