Scolaro, L.Lorenser, D.Madore, W.Kirk, R.Kramer, A.Yeoh, G.Godbout, N.Sampson, D.Boudoux, C.McLaughlin, R.2016-11-102016-11-102015Biomedical Optics Express, 2015; 6(5):1767-17812156-70852156-7085http://hdl.handle.net/2440/102432Molecular imaging using optical techniques provides insight into disease at the cellular level. In this paper, we report on a novel dualmodality probe capable of performing molecular imaging by combining simultaneous three-dimensional optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may be inserted tens of millimeters into tissue. The MI needle utilizes double-clad fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system and a fluorescence imaging subsystem using an asymmetrical double-clad fiber coupler customized to achieve high fluorescence collection efficiency. We present, to the best of our knowledge, the first dual-modality OCT and fluorescence needle probe with sufficient sensitivity to image fluorescently labeled antibodies. Such probes enable high-resolution molecular imaging deep within tissue.en©2015 Optical Society of America. Open Access(110.2350) Fiber optics imaging(170.0180) Microscopy(170.2520) Fluorescence microscopy(170.4500) Optical coherence tomographyJournal article003005032410.1364/BOE.6.0017670003539271000172-s2.0-84948764663256183McLaughlin, R. [0000-0001-6947-5061]