Kelada, L.Wakefield, C.Vidic, N.Armstrong, D.S.Bennetts, B.Boggs, K.Christodoulou, J.Harrison, J.Ho, G.Kapur, N.Lindsey-Temple, S.McDonald, T.Mowat, D.Schultz, A.Selvadurai, H.Tai, A.Jaffe, A.2023-03-222023-03-222022BMJ Open Respiratory Research, 2022; 9(1)2052-44392052-4439https://hdl.handle.net/2440/137688Objective Research is needed to determine best practice for genomic testing in the context of child interstitial or diffuse lung disease (chILD). We explored parent’s and child’s health-related quality of life (HRQoL), parents’ perceived understanding of a genomic testing study, satisfaction with information and the study and decisional regret to undertake genomic testing. Methods Parents of children with diagnosed or suspected chILD who were enrolled in a genomic sequencing study were invited to complete questionnaires pretesting (T1) and after receiving the result (T2). Results Parents’ (T1, n=19; T2, n=17) HRQoL was lower than population norms. Study satisfaction (T1) and perceived understanding (T2) were positively correlated (rs=0.68, p=0.014). Satisfaction with information (T1 and T2) and decisional regret (T2) were negatively correlated (T1 rs=−0.71, p=0.01; T2 rs=−0.56, p=0.03). Parents reported wanting more frequent communication with staff throughout the genomic sequencing study, and greater information about the confidentiality of test results. Conclusions Understanding of genomic testing, satisfaction with information and participation and decisional regret are inter-related. Pretest consultations are important and can allow researchers to explain confidentiality of data and the variable turnaround times for receiving a test result. Staff can also update parents when there will be delays to receiving a result.en© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.HumansLung DiseasesPersonal SatisfactionParentsQuality of LifeChildGenetic TestingHumansLung DiseasesPersonal SatisfactionParentsQuality of LifeChildGenetic TestingJournal article10.1136/bmjresp-2021-0011392023-03-22605342Tai, A. [0000-0001-9240-5416]