Simpson, B.Claudie, D.Gerber, J.Pyke, S.Wang, J.McKinnon, R.Semple, S.2011-10-212011-10-212011Journal of Natural Products, 2011; 74(4):650-6570163-38641520-6025http://hdl.handle.net/2440/66953Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.enCopyright © 2011 The American Chemical Society and American Society of PharmacognosyEarAnimalsMiceSapindaceaePlant LeavesPlant StemsDisease Models, AnimalEdemaDiterpenes, ClerodaneTetradecanoylphorbol AcetateAnti-Inflammatory Agents, Non-SteroidalMolecular StructureAustraliaJournal article002010615110.1021/np100701s0002897423000172-s2.0-7995539903530851Pyke, S. [0000-0002-0061-5115]