Johnston, I.Tan, M.Cao, J.Matsos, A.Forrest, D.Si, E.Fardell, J.Hutchinson, M.2018-03-082018-03-082017Behavioural Brain Research, 2017; 334:109-1180166-43281872-7549http://hdl.handle.net/2440/110917Chemotherapy can cause serious neurotoxic side effects, such as painful peripheral neuropathies and disabling cognitive impairments. Four experiments examined whether Ibudilast, a clinically approved neuroimmune therapy, would reduce tactile allodynia and memory impairments caused by oxaliplatin in laboratory rats. Rats received an intraperitoneal injection of oxaliplatin (6mg/kg i.p.) or vehicle and were assessed for tactile allodynia 3 or 5days after injection, memory impairments in the novel object and novel location recognition tests 10-12days after injection, and fear conditioning 14days after injection. Ibudilast (7.5mg/kg) or vehicle was administered prior to oxaliplatin (Experiments 1 and 3) or prior to behavioural testing (Experiments 2 and 4). Ibudilast treatment prior to oxaliplatin prevented the development of tactile allodynia and memory impairments. Ibudilast treatment prior to behavioural testing reduced oxaliplatin-induced tactile allodynia, memory impairments, and impaired renewal of fear conditioning. These results suggest that Ibudilast could be an effective treatment against oxaliplatin-induced neuropathies and cognitive impairments.en© 2017 Elsevier B.V. All rights reserved.Oxaliplatin; chemotherapy; neuropathic pain; memory impairment; ibudilastJournal article003007442010.1016/j.bbr.2017.07.0210004113022000142-s2.0-85026676959365712Hutchinson, M. [0000-0003-2154-5950]