Lee, M.H.Shroff, R.Cooper, S.Hope, R.2006-07-052006-07-051999Molecular Phylogenetics and Evolution, 1999; 12(2):205-2141055-79031095-9513http://hdl.handle.net/2440/11484Coinciding with a period in evolution when monotremes, marsupials, and eutherians diverged from a common ancestor, a proto-beta-globin gene duplicated, producing the progenitors of mammalian embryonic and adult beta-like globin genes. To determine whether monotremes contain orthologues of these genes and to further investigate the evolutionary relationships of monotremes, marsupials, and eutherians, we have determined the complete DNA sequence of an echidna (Tachyglossus aculeatus) beta-like globin gene. Conceptual translation of the gene and sequence comparisons with eutherian and marsupial beta-like globin genes and echidna adult beta-globin indicate that the gene is adult expressed. Phylogenetic analyses do not clearly resolve the branching pattern of mammalian beta-like globin gene lineages and it is therefore uncertain whether monotremes have orthologues of the embryonic beta-like globin genes of marsupials and eutherians. Four models are proposed that provide a framework for interpreting further studies on the evolution of beta-like globin genes in the context of the evolution of monotremes, marsupials, and eutherians.enCopyright © 1999 by Academic Press. All rights of reproduction in any form reserved.AnimalsMarsupialiaGlobinsBlotting, SouthernCloning, MolecularSequence Analysis, DNAEvolution, MolecularPhylogenyAmino Acid SequenceBase SequenceMutationIntronsModels, GeneticMolecular Sequence DataAustraliaPromoter Regions, GeneticGenetic VariationTachyglossidaeJournal article0030004279001999085010.1006/mpev.1999.06102-s2.0-003316152568285Cooper, S. [0000-0002-7843-8438]