Reddi, B.2013-07-232013-07-232013International Journal of Medical Sciences, 2013; 10(6):747-7501449-19071449-1907http://hdl.handle.net/2440/78905Commercial 0.9% saline solution for infusion has a pH around 5.5. There are many reasons for this acidity, some of them still obscure. It is also true that infusion of normal saline can lead to met-abolic acidaemia, yet the link between the acidity of saline solution and the acidaemia it can en-gender is not straightforward. This commentary draws together the known and putative sources of acidity in saline solutions: it turns out that the acidity of saline solution is essentially unrelated to the acidaemia complicating saline infusion.en© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.salineacidaemiatitratable aciditycrystalloidbalanced solutionGrotthuss.Journal article002012833510.7150/ijms.58682-s2.0-8487642807619499