Thornton, E.Ziebell, J.Leonard, A.Vink, R.2010-12-162010-12-162010Molecules, 2010; 15(9):6598-66181420-30491420-3049http://hdl.handle.net/2440/61989Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.en© 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).brain injuryneurotraumastrokeneuropeptideskininsJournal article002010097310.3390/molecules150965980002822211000532-s2.0-7795731487733233Leonard, A. [0000-0002-9430-3314]Vink, R. [0000-0002-4885-0667]