Ayalew, G.Assefa, A.Amsalu, A.Geta, M.Mihret, A.Aseffa, A.Howe, R.Abate, E.2025-12-182025-12-182019Ethiopian Medical Journal, 2019; 57(2):137-1440014-1755https://hdl.handle.net/11541.2/34193Background: Hepatitis B virus infection is a worldwide health problem and highly endemic in developing countries including Ethiopia. Hepatitis B vaccine is included in the routine Expanded Program on Immunization since 2007 in Ethiopia. Objective: The aim of this study was to assess the sero-protection level of hepatitis B vaccination among children who have received the vaccine. Methods: A cross-sectional study was conducted among children attending Kindergarten and first cycle elementary school in Gondar town. A pre-tested structured questionnaire was used to collect the socio-demographic data. Blood sample was collected and serum separated for anti-HBs,anti-HBc and HBsAg. The data was analyzed using SPSS statistical software version 20. Binary logistic regression analysis was done. P-value less than 0.05 was considered as statistically significant. Result:Out of 431 children screened, 27 were excluded from analysis because they were positive for anti-HBc(27/431, 6.3%) and/or for HBsAg (18/431 or 4.2%). Out of 404 children, 130 (32.2%) had anti-HBs titers >10 mIU/ml (seroprotected) while 274 (68.8%) had anti-HBs titers <10 mIU/ml (non-protected).enCopyright 2019 The author(s).Hepatitis B virusEthiopiavaccinationchildrenJournal article2-s2.0-85081719360