Ward, S.A.Storey, E.Gasevic, D.Naughton, M.T.Hamilton, G.S.Trevaks, R.E.Wolfe, R.O'Donoghue, F.J.Stocks, N.Abhayaratna, W.P.Fitzgerald, S.Orchard, S.G.Ryan, J.McNeil, J.J.Reid, C.M.Woods, R.L.2022-05-302022-05-302022Respirology, 2022; 27(9):767-7751323-77991440-1843https://hdl.handle.net/2440/135279First published: 17 May 2022Background and objective:The clinical significance of sleep-disordered breathing(SDB) in older age is uncertain. This study determined the prevalence and associations of SDB with mood, daytime sleepiness, quality of life (QOL) and cognition in a relatively healthy older Australian cohort. Methods: A cross-sectional analysis was conducted from the Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea. Participants completed an unattended limited channel sleep study to measure the oxygen desaturation index (ODI) to define mild (ODI 5–15) and moderate/severe (ODI≥15)SDB, the Centre for Epidemiological Studies Scale, the Epworth Sleepiness Scale, the12-item Short-Form for QOL and neuropsychological tests. Results: Of the 1399 participants (mean age 74.0 years), 36% (273 of 753) of men and25% (164 of 646) of women had moderate/severe SDB. SDB was associated with lower physical health-related QOL (mild SDB: beta coefficient [β]- 2.5, 95% CI- 3.6 to- 1.3,p< 0.001; moderate/severe SDB:β -1.8, 95% CI - 3.0 to -0.6,p=0.005) and with lower global composite cognition (mild SDB:β - 0.1, 95% CI - 0.2 to 0.0,p=0.022; moderate/severe SDB:β 0.1, 95% CI - 0.2 to 0.0,p=0.032) compared to no SDB. SDB was not associated with daytime sleepiness nor depression.Conclusion:SDB was associated with lower physical health-related quality of life and cognitive function. Given the high prevalence of SDB in older age, assessing QOL and cognition may better delineate subgroups requiring further management, and provide useful treatment target measures for this age group.en© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.ageingcognitiondementiaquality of lifesleep-disordered breathingJournal article10.1111/resp.142792022-05-30612788Stocks, N. [0000-0002-9018-0361]