Smyth, G.Verbyla, A.2006-06-232006-06-231996Journal- Royal Statistical Society Series B, 1996; 58(3):565-5720035-9246http://hdl.handle.net/2440/5147Residual maximum likelihood (REML) estimation is often preferred to maximum likelihood estimation as a method of estimating covariance parameters in linear models because it takes account of the loss of degrees of freedom in estimating the mean and produces unbiased estimating equations for the variance parameters. In this paper it is shown that REML has an exact conditional likelihood interpretation, where the conditioning is on an appropriate sufficient statistic to remove dependence on the nuisance parameters. This interpretation clarifies the motivation for REML and generalizes directly to non-normal models in which there is a low dimensional sufficient statistic for the fitted values. The conditional likelihood is shown to be well defined and to satisfy the properties of a likelihood function, even though this is not generally true when conditioning on statistics which depend on parameters of interest. Using the conditional likelihood representation, the concept of REML is extended to generalized linear models with varying dispersion and canonical link. Explicit calculation of the conditional likelihood is given for the one-way lay-out. A saddlepoint approximation for the conditional likelihood is also derived.en© 1996 Royal Statistical SocietyConditional Likelihood; Exponential Dispersion Model; Modified Profile Likelihood; One-Way Lay-Out; Residual Maximum Likelihood; Restricted Maximum Likelihood; Saddlepoint ApproximationJournal article0030006361001996390570367