Burlakoti, A.Kumaratilake, J.Taylor, J.Henneberg, M.2025-07-092025-07-092021BMJ Open, 2021; 11(9):e051028-1-e051028-82044-60552044-6055https://hdl.handle.net/2440/145802Objective: Segments of cerebral basal arterial network (CBAN) dampen the peak pressure in blood flowing through these arteries, thus minimising the chances of development of cerebral aneurysms. The objective of this research was to find the relationship of occurrence of intracranial aneurysms to variations of the components of the CBAN. Design and setting: This is an observational, quantitative and retrospective research, which used cerebral CT angiography (CCTA) images. Participants: Cerebral CTA of 145 adult patients of both sexes were studied. Main outcome measures: Diameters of segments of CBAN were measured in CCTA images and the relative size of each vessel was calculated to standardise for differences in overall arterial sizes among patients. Relationships among sizes of CBAN components were analysed. Presence of aneurysms in different parts of the CBAN was recorded. Results: Forty-six aneurysms in right internal carotid artery (ICA) and middle cerebral artery (MCA) and 32 aneurysms in left ICA and MCA segments were noted in 42 and 30 patients, respectively. Aneurysms in anterior communicating artery complex and vertebral-basilar arterial segments were seen in 27 and 8 patients, respectively, while they were not detected in parts of posterior cerebral artery (PCA). The significant (p<0.001) inverse relationships between sizes of posterior communicating artery and the first segment of PCA on both sides indicated that blood inputs to the second part of PCA were similar. Difference in means of the index of arterial size variation for people with aneurysms (mean 0.96, SD 0.23) and without aneurysms (mean 0.86, SD 0.22) was significant (p=0.015). Conclusion: Variation in segments of CBAN was quantified. The peak pressure dampening mechanism in such arterial segments reduces the chances of development of aneurysms.en© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Open access This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.cerebral basal arterial network (CBAN); blood flow; cerebral aneurysms; intracranial aneurysmsCarotid Artery, InternalHumansIntracranial AneurysmTomography, X-Ray ComputedCerebral AngiographyRetrospective StudiesCross-Sectional StudiesAdultFemaleMaleJournal article10.1136/bmjopen-2021-0510282024-02-20587963Burlakoti, A. [0000-0001-9317-6352]Kumaratilake, J. [0000-0001-5904-7629]Henneberg, M. [0000-0003-1941-2286]