Sleebs, M.Scanlon, D.Karas, J.Maharani, R.Hughes, A.2012-06-012012-06-012011Journal of Organic Chemistry, 2011; 76(16):6686-66930022-32631520-6904http://hdl.handle.net/2440/71355Publication Date (Web): July 8, 2011We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.en© 2011 American Chemical SocietyAmidesPeptides, CyclicDepsipeptidesAntifungal AgentsMolecular StructureCyclizationJournal article10.1021/jo201017w2-s2.0-80051768276