Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

Obando, D.Pantarat, N.Handke, R.Koda, Y.Widmer, F.Djordjevic, J.Ellis, D.Sorrell, T.Jolliffe, K.2009-10-192009-10-192009Bioorganic and Medicinal Chemistry, 2009; 17(17):6329-63390968-08961464-3391http://hdl.handle.net/2440/51191Available online 23 July 2009.A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.enCopyright © 2009 Elsevier Ltd. All rights reservedBispyridiniumAntifungal activityHaemolytic activityFungal phospholipase BSynthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanesJournal article002009222610.1016/j.bmc.2009.07.0370002690291000232-s2.0-6894910871437849Ellis, D. [0000-0002-7283-4667]