Khoury, D.S.Cao, P.Zaloumis, S.G.Davenport, M.P.The Interdisciplinary Approaches to Malaria Consortium,2022-01-132022-01-132020Trends in Parasitology, 2020; 36(11):884-8870169-47581471-5007https://hdl.handle.net/2440/134063Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.en© 2020 Elsevier Ltd. All rights reserved.Malaria; drug resistance; artemisinin; selection pressureAnimalsHumansPlasmodiumArtemisininsAntimalarialsInhibitory Concentration 50Drug ResistanceSelection, GeneticArtemisinin resistance and the unique selection pressure of a short-acting antimalarialJournal article10.1016/j.pt.2020.07.0042022-01-13595316