Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/23297
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DC Field | Value | Language |
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dc.contributor.author | Hofman, T. | - |
dc.contributor.author | Cranswick, N. | - |
dc.contributor.author | Kuna, P. | - |
dc.contributor.author | Boznanski, A. | - |
dc.contributor.author | Latos, T. | - |
dc.contributor.author | Gold, M. | - |
dc.contributor.author | Murrell, D. | - |
dc.contributor.author | Gebauer, K. | - |
dc.contributor.author | Behre, U. | - |
dc.contributor.author | Machura, E. | - |
dc.contributor.author | Olafsson, J. | - |
dc.contributor.author | Szalai, Z. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Archives of Disease in Childhood, 2006; 91(11):905-910 | - |
dc.identifier.issn | 0003-9888 | - |
dc.identifier.issn | 1468-2044 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23297 | - |
dc.description.abstract | Background: Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression. Aims: In a 7-month, multicentre, randomised, controlled trial, we investigated the equivalence of response to vaccination against meningococcal serogroup C disease with a protein-conjugate vaccine in children (2–11 years) with moderate to severe atopic dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 21) or a hydrocortisone ointment regimen (HC-O; n = 111). Methods: TAC-O was applied twice daily (bid) for 3 weeks, and thereafter daily until clearance. 1% hydrocortisone acetate (HA) for head/neck and 0.1% hydrocortisone butyrate ointment for trunk/limbs was applied bid for 2 weeks; thereafter HA was applied bid to all affected areas. At week 1, patients were vaccinated with protein-conjugate vaccine against meningococcal serogroup C, and challenged at month 6 with low dose meningococcal polysaccharide vaccine. The control group (44 non-atopic dermatatits children) received the primary vaccination and challenge dose. Assessments were made at baseline, weeks 1 and 5, and months 6 and 7. The primary end point was the percentage of patients with a serum bactericidal antibody (SBA) titre 8 at the week 5 visit. Results: The response rate (patients with SBA titre 8) was 97.5% (confidence interval (CI) approximately 97.3 to 100), 99.1% (94.8 to 100) and 97.7% (93.3 to 100) in the TAC-O, HC-O and control groups, respectively. Conclusions: The immune response to vaccination against meningococcal serogroup C in children with atopic dermatitis applying either 0.03% TAC-O or HC is equivalent. Ointment application does not affect the immediate response to vaccination, generation of immune memory or humoral and cell-mediated immunity. | - |
dc.description.statementofresponsibility | T Hofman, N Cranswick, P Kuna, A Boznanski, T Latos, M Gold, D F Murrell, K Gebauer, U Behre, E Machura, J Ólafsson, Z Szalai | - |
dc.language.iso | en | - |
dc.publisher | British Med Journal Publ Group | - |
dc.rights | Copyright © 2006 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health | - |
dc.source.uri | http://dx.doi.org/10.1136/adc.2006.094276 | - |
dc.subject | International Tacrolimus Ointment Study Group | - |
dc.subject | Humans | - |
dc.subject | Neisseria meningitidis, Serogroup C | - |
dc.subject | Meningococcal Infections | - |
dc.subject | Dermatitis, Atopic | - |
dc.subject | Tacrolimus | - |
dc.subject | Immunosuppressive Agents | - |
dc.subject | Antigens, CD | - |
dc.subject | Meningococcal Vaccines | - |
dc.subject | Immunoglobulin Isotypes | - |
dc.subject | Administration, Topical | - |
dc.subject | Double-Blind Method | - |
dc.subject | Immunity, Cellular | - |
dc.subject | Immunologic Memory | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Tacrolimus ointment does not affect the immediate response to vaccination, the generation of immune memory, or humoral and cell-mediated immunity in children | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/adc.2006.094276 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Gold, M. [0000-0003-1312-5331] | - |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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