Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/28084
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Sequence comparison of an Australian duck hepatitis B virus strain with other avian hepadnaviruses |
Author: | Triyatni, M. Ey, P. Tran, T. Le Mire, M. Qiao, M. Burrell, C. Jilbert, A. |
Citation: | Journal of General Virology, 2001; 82(Part 2):373-378 |
Publisher: | Soc General Microbiology |
Issue Date: | 2001 |
ISSN: | 0022-1317 1465-2099 |
Statement of Responsibility: | Miriam Triyatni, Peter L. Ey, Thien Tran, Marc Le Mire, Ming Qiao, Christopher J. Burrell, and Allison R. Jilbert |
Abstract: | The genome of an Australian strain of duck hepatitis B virus (AusDHBV) was cloned from a pool of congenitally DHBV-infected-duck serum, fully sequenced and found by phylogenetic analyses to belong to the ‘Chinese’ DHBV branch of the avian hepadnaviruses. Sequencing of the Pre-S/S gene of four additional AusDHBV clones demonstrated that the original clone (pBL4.8) was representative of the virus present in the pool, and a head-to-tail dimer of the clone was infectious when inoculated into newly hatched ducks. When the published sequences of 20 avian hepadnaviruses were compared, substitutions or deletions in the polymerase (POL) gene were most frequent in the 500 nt segment encoding the ‘spacer’ domain that overlaps with the Pre-S domain of the Pre-S/S gene in a different reading frame. In contrast, substitutions and deletions were rare within the adjacent segment that encodes the reverse transcriptase domain of the POL protein and the S domain of the envelope protein, presumably because they are more often deleterious. |
Keywords: | Animals Ducks Geese Hepatitis B Virus, Duck Viral Proteins Cloning, Molecular Phylogeny Protein Structure, Tertiary Mutation Genome, Viral Molecular Sequence Data Australia |
Description: | © 2001 Society for General Microbiology |
DOI: | 10.1099/0022-1317-82-2-373 |
Description (link): | http://vir.sgmjournals.org/ |
Published version: | http://dx.doi.org/10.1099/0022-1317-82-2-373 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.