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https://hdl.handle.net/2440/52211
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Type: | Journal article |
Title: | Apnea-Associated Reduction in Lower Esophageal Sphincter Tone in Premature Infants |
Author: | Omari, T. |
Citation: | Journal of Pediatrics, 2009; 154(3):374-378 |
Publisher: | Mosby Inc |
Issue Date: | 2009 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Taher I. Omari |
Abstract: | <h4>Objective</h4>To characterize esophageal motility during episodes of prolonged apnea in premature infants.<h4>Study design</h4>We retrospectively reviewed combined manometric and physiological monitoring studies performed in tube-fed premature infants from 1994 to 2002. Apnea was defined as a respiratory pause of >20 seconds. For each apneic event, pharyngeal swallowing, esophageal motility, and lower esophageal sphincter (LES) pressure were assessed before, during, and after apneic episodes.<h4>Results</h4>Twelve episodes of apnea (duration, 20 to 120 seconds) were identified in 7 infants (34 to 37 weeks postmenstrual age (PMA); study weight, 1950 to 2380 g). During the apneic episodes, swallowing increased (median[interquartile range], 0[0,0], 5[4,7], and 1[0,2] swallows/minute before, during, and after apnea, respectively; P < .05), esophageal pressure wave sequences (PWS) increased (1[0,2], 5[3,6], and 2[1,3] PWS/minute before, during, and after apnea, respectively; P < .05) and LES pressure decreased (16[12,21], 6[5,8], and 27[12,32] mmHg before, during, and after apnea, respectively; P < .05).<h4>Conclusion</h4>In premature infants, apnea is associated with reduced LES tone, potentially increasing the likelihood of reflux occurring after the onset of apnea. |
Keywords: | Esophageal Sphincter, Lower Humans Esophageal Motility Disorders Apnea Infant, Premature, Diseases Monitoring, Physiologic Retrospective Studies Manometry Deglutition Pressure Infant, Newborn Infant, Premature |
DOI: | 10.1016/j.jpeds.2008.09.009 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2008.09.009 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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