Adelaide Research & Scholarship
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https://hdl.handle.net/2440/7227
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| Type: | Journal article |
| Title: | The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice |
| Author: | Symonds, E. Butler, R. Omari, T. |
| Citation: | European Journal of Pharmacology, 2003; 470(1-2):95-97 |
| Publisher: | Elsevier Science BV |
| Issue Date: | 2003 |
| ISSN: | 0014-2999 1879-0712 |
| Abstract: | The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying. |
| Keywords: | Animals Mice, Inbred C57BL Mice Baclofen Receptors, GABA-B GABA Agonists Gastric Emptying Female GABA-B Receptor Agonists |
| DOI: | 10.1016/S0014-2999(03)01779-5 |
| Published version: | http://dx.doi.org/10.1016/s0014-2999(03)01779-5 |
| Appears in Collections: | Aurora harvest Paediatrics publications |
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