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Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/74506

Type: Journal article
Title: Normal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine production
Author: Gomez-Lopez, Nardhy Yadira
Hernandez-Santiago, Susana
Lobb, Andrew Peter
Olson, David M.
Vadillo-Ortega, Felipe
Citation: Reproductive Sciences, 2013; 20(3):276-284
Publisher: Sage Publications
Issue Date: 2013
ISSN: 1933-7191
School/Discipline: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology
Statement of
Responsibility: 
Nardhy Gomez-Lopez, Susana Hernandez-Santiago, Andrew P. Lobb, David M. Olson, and Felipe Vadillo-Ortega
Abstract: A gradient of immunological mediators exists in the fetal membranes from the periplacental zone (PZ) to the rupture zone (RZ) at term delivery (rupture of fetal membranes [ROM]). However, it is unknown if this gradient is different in premature rupture of these tissues (premature rupture of fetal membranes [PROM]). We therefore analyzed leukocyte chemotactic activity and chemokine/cytokine production in fetal membrane zones in ROM and PROM. In ROM, leukocyte chemotactic activity increased from the PZ to the RZ; however, this did not occur in PROM. This was due to consistently elevated leukocyte chemotactic activity in PROM compared to ROM tissues. In the RZ, ROM was characterized by increased T-cell attraction and high levels of chemokine (C-X-C motif) ligand 8 (CXCL-8)/interleukin 8, and PROM by increased granulocyte attraction and high levels of granulocyte-macrophage colony-stimulating factor and CXCL-10/interferon gamma-induced protein 10. We conclude that normal and premature rupture of fetal membranes differ in regional chemotactic activity and related chemokine/cytokine production, which may represent evidence for differential mechanisms of rupture at term delivery.
Keywords: chemotactic activity; fetal membranes; labor; leukocytes; PROM; ROM
Rights: © The Author(s) 2012
RMID: 0020122438
DOI: 10.1177/1933719112452473
Appears in Collections:Obstetrics and Gynaecology publications
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