Adelaide Research & Scholarship
Adelaide Research & Scholarship (AR&S) is the University of Adelaide’s digital repository. AR&S provides a platform for the collection, organisation, access and preservation of the research and scholarly outputs of the University community in digital formats, as well as digital management of information in physical formats.
University of Adelaide higher degree by research theses are deposited into the AR&S Theses community as part of the final thesis lodgement process.
AR&S also serves as the home of the digital collections of University Library Archives and Special Collections. Items include digitized representations of physical items, such as photographs and full texts, and digital-born materials, allowing worldwide access to our heritage and research collections.
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Recent Submissions
Author Rejoinders and Reflections: III P T Babie
(Routledge, 2025) Babie, P.; Barker, R.; Andersen, C.; Rasmi Alumari, M.
Response to Matt Watson, ‘A Socio-Legal Explication of the Divergent Legal Approaches to State Funding of Religious Schools in Canada and the United States
(Routledge, 2025) Babie, P.; Barker, R.; Andersen, C.; Rasmi Alumari, M.
Although Canada and the United States share a physical border, the same cannot be said of the constitutional treatment of the metaphysical boundary between church and state. As Matt Watson so ably shows in Chapter 6, as they arise in relation to public funding for religious schools, and in the absence in Canada of a constitutional bar to such funding, the legal differences between the two nations represent the product of divergent constitutional histories. In revealing these dual histories, Watson: advances an explanatory argument [that] [i]ntegrat[es] historical narratives, philosophical underpinnings, and societal dynamics and demographics, propos[ing] a multifaceted, interdisciplinary explanation for why American and Canadian legal doctrines around state funding for religious schools diverge so substantially.
Express Directors’ Duties for Cybersecurity: Resilience through Adaptation
(Springer, 2025) Nosworthy, B.; Stephens, D.; Stubbs, M.; White, S.
Elements of corporate governance have been evident for almost as long as there has been an understanding of the corporate form, and it has always had to adapt to new challenges presented in each era. This chapter considers the modern challenge of cybersecurity risk and identifies existing resilience in the current Australian directors’ duties in light of their historical origins and prior adaptation, which enable them to respond to cybersecurity risk. Through careful consideration of analogous examples provided in existing case law in relation to the directors’ duties of care and loyalty, this chapter articulates the capacity of the current laws to hold senior corporate decision-makers accountable where they do not meet the expected standard of behaviour. The particular risks associated with cybersecurity are articulated and contrasted to extant risks regularly assessed and addressed by boards of directors, confirming the resilience of the directors’ duty regime in responding to this challenge.
Electroconductive Antibacterial Bioinks Enable Electrical Stimulation Enhancement of Proliferation and Elongation of Human Skin Fibroblasts.
(American Chemical Society, 2025) Le, H.-P.; Hassan, K.; Alsenaide, M.; Purasinhala, K.; Tran, A.T.T.; Ramezanpour, M.; Al-Sarawi, S.; Tung, T.T.; Vreugde, S.; Losic, D.
The limited electrical conductivity and poor antibacterial performance of many existing bioinks hinder their effectiveness in wound healing applications, where mimicking the native electrical properties of skin and preventing infection are critical. In this study, we developed multifunctional electroconductive and antibacterial bioinks designed to work synergistically with electrical stimulation (ES) therapy to overcome these limitations. These new bioinks are formulated by integrating the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT: PSS) into a carboxymethyl cellulose (CMC) and alginate (ALG) biopolymer matrix, followed by ionic cross-linking using Ga³⁺ ions. The CMC/ALG network provided favorable rheological properties for 3D bioprinting, while PEDOT:PSS imparted electrical conductivity to the resulting hydrogels. Cross-linking with Ga³⁺ with the carboxylic groups on the polymer chains enhanced the structural stability of the hydrogels and conferred antibacterial activity against both Gram-negative (Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria. The engineered bioinks also supported excellent cellular support during bioprinting, as nearly 100% bioprinted cells were viable. When combined with ES, the Ga3+-cross-linked CMC/ALG/PEDOT:PSS bioinks significantly enhanced the elongation and proliferation of human skin fibroblasts over 9 days of culture. These results demonstrate the potential of this conductive, antibacterial, and cell-compatible bioink platform, augmented by ES, as a promising strategy to accelerate wound healing and skin tissue regeneration.
High protein does not change autophagy in human peripheral blood mononuclear cells after one hour
(American Society for Clinical investigation, 2025) Singh, S.; Fourrier, C.; Hattersley, K.J.; Hein, L.K.; Gore, J.; Martin, A.; Dang, L.V.; King, B.; Protzman, R.A.; Trim, P.J.; Heilbronn, L.K.; Bensalem, J.; Sargeant, T.J.
Autophagy is a catabolic quality control pathway that has been linked to neurodegenerative disease, atherosclerosis and ageing, and can be modified by nutrient availability in preclinical models. Consequently, there is immense public interest in stimulating autophagy in people. However, progress has been hampered by the lack of techniques to measure human autophagy. As a result, several key concepts in the field, including nutritional modulation of autophagy, have yet to be validated in humans. We conducted a single arm pre-post study in 42 healthy individuals, to assess whether an acute nutritional intervention could modify autophagy in humans. Two blood samples were collected per participant: after a 12 h overnight fast and 1 h post-consumption of a high protein meal. Autophagy turnover was assessed using a physiologically relevant measure of autophagic flux in peripheral blood mononuclear cells. A lysosomal inhibitor was added directly to whole blood, with the resulting build-up of autophagy marker LC3B-II designated as flux, and measured quantitatively via ELISA. Notably, consumption of a high protein meal had no impact on autophagy, with no differences between overnight fasting and postprandial autophagic flux. We observed sexual dimorphism in autophagy, with females having higher autophagic flux compared to males (p = 0.0031). Exploratory analyses revealed sex-specific correlations between autophagy, insulin and glucose signalling. Importantly, our findings show that an acute nutritional intervention (overnight fasting followed by consumption of a protein-rich meal) does not change autophagic flux in humans, highlighting the need to conduct further autophagy studies in humans.