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Type: Journal article
Title: Prolonged survival follows resection of oesophageal SCC downstaged by prior chemoradiotherapy
Author: Bessell, J.
Devitt, P.
Gill, P.
Goyal, S.
Jamieson, G.
Citation: ANZ Journal of Surgery, 1996; 66(4):214-217
Issue Date: 1996
ISSN: 0004-8682
Abstract: <h4>Background</h4>The poor survival rate of surgically treated patients with oesophageal cancer has not improved substantially over the last 25 years, but combined modality therapy has shown early promising results.<h4>Methods</h4>A prospective study was undertaken to determine the effect of pre-operative synchronous chemoradiotherapy followed by oesophagectomy in 53 patients with squamous cell carcinoma (SCC) of the oesophagus. The patient group was unselected, other than by fitness for surgery.<h4>Results</h4>In 25% of patients, complete pathological regression of the tumour was achieved. All but one of the patients in this subgroup had T2 tumours on pre-operative clinical staging and two had evidence of lymph node involvement, but postoperative pathological examination revealed that pre-operative chemoradiotherapy had downstaged their disease to T0N0. There was no hospital mortality in this subgroup and the actuarial 7 year survival was 69%.<h4>Conclusions</h4>For squamous oesophageal tumours deep to the submucosa this is an extremely good survival. For the present, this form of therapy for SCC of the oesophagus appears capable of achieving results comparable to, or better than, those reported for 3-field lymphadenectomy.
Keywords: Humans
Carcinoma, Squamous Cell
Esophageal Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Neoplasm Staging
Treatment Outcome
Chemotherapy, Adjuvant
Radiotherapy, Adjuvant
Survival Analysis
Prospective Studies
Middle Aged
DOI: 10.1111/j.1445-2197.1996.tb01167.x
Appears in Collections:Aurora harvest 4
Surgery publications

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