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Type: Journal article
Title: Oocyte maturation and quality: role of cyclic nucleotides
Author: Gilchrist, R.
Luciano, A.
Richani, D.
Zeng, H.
Wang, X.
De Vos, M.
Sugimura, S.
Smitz, J.
Richard, F.
Thompson, J.
Citation: Reproduction, 2016; 152(5):R143-R157
Publisher: BioScientifica
Issue Date: 2016
ISSN: 1470-1626
Statement of
Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, De Vos M, Sugimura S, Smitz J, Richard FJ and Thompson JG
Abstract: The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options.
Keywords: Oocytes; Animals; Humans; Nucleotides, Cyclic; Oogenesis; Female; In Vitro Oocyte Maturation Techniques
Description: Advance Publication first posted online on 15 July 2016 - Accepted manuscript
Rights: Copyright © 2016 Society for Reproduction and Fertility
RMID: 0030051743
DOI: 10.1530/REP-15-0606
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Appears in Collections:IPAS publications

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