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|Title:||The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma.|
|Citation:||Cancer Letters, 1999; 143(1):29-35|
|Publisher:||ELSEVIER SCI IRELAND LTD|
|Abstract:||Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.|
|Keywords:||Intestinal Mucosa; Jurkat Cells; Humans; Adenoma; Carcinoma; Colorectal Neoplasms; Coumarins; Enzyme Precursors; Caspases; Amino Acid Chloromethyl Ketones; Oligopeptides; Cysteine Proteinase Inhibitors; Apoptosis; Adult; Aged; Aged, 80 and over; Middle Aged; Female; Male; Caspase 3; Caspase Inhibitors|
|Appears in Collections:||Surgery publications|
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