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https://hdl.handle.net/2440/10114
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Type: | Journal article |
Title: | The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma. |
Author: | Leonardos, L. Butler, L. Hewett, P. Zalewski, P. Cowled, P. |
Citation: | Cancer Letters, 1999; 143(1):29-35 |
Publisher: | ELSEVIER SCI IRELAND LTD |
Issue Date: | 1999 |
ISSN: | 0304-3835 1872-7980 |
Abstract: | Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis. |
Keywords: | Intestinal Mucosa Jurkat Cells Humans Adenoma Carcinoma Colorectal Neoplasms Coumarins Enzyme Precursors Caspases Amino Acid Chloromethyl Ketones Oligopeptides Cysteine Proteinase Inhibitors Apoptosis Adult Aged Aged, 80 and over Middle Aged Female Male Caspase 3 Caspase Inhibitors |
DOI: | 10.1016/S0304-3835(99)00176-7 |
Published version: | http://dx.doi.org/10.1016/s0304-3835(99)00176-7 |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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