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Type: Journal article
Title: The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma.
Author: Leonardos, L.
Butler, L.
Hewett, P.
Zalewski, P.
Cowled, P.
Citation: Cancer Letters, 1999; 143(1):29-35
Issue Date: 1999
ISSN: 0304-3835
Abstract: Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.
Keywords: Intestinal Mucosa; Jurkat Cells; Humans; Adenoma; Carcinoma; Colorectal Neoplasms; Coumarins; Enzyme Precursors; Caspases; Amino Acid Chloromethyl Ketones; Oligopeptides; Cysteine Proteinase Inhibitors; Apoptosis; Adult; Aged; Aged, 80 and over; Middle Aged; Female; Male; Caspase 3; Caspase Inhibitors
RMID: 0030004651
DOI: 10.1016/S0304-3835(99)00176-7
Appears in Collections:Surgery publications

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