Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/10114
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Type: Journal article
Title: The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma.
Author: Leonardos, L.
Butler, L.
Hewett, P.
Zalewski, P.
Cowled, P.
Citation: Cancer Letters, 1999; 143(1):29-35
Publisher: ELSEVIER SCI IRELAND LTD
Issue Date: 1999
ISSN: 0304-3835
1872-7980
Abstract: Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.
Keywords: Intestinal Mucosa
Jurkat Cells
Humans
Adenoma
Carcinoma
Colorectal Neoplasms
Coumarins
Enzyme Precursors
Caspases
Amino Acid Chloromethyl Ketones
Oligopeptides
Cysteine Proteinase Inhibitors
Apoptosis
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Caspase 3
Caspase Inhibitors
DOI: 10.1016/S0304-3835(99)00176-7
Published version: http://dx.doi.org/10.1016/s0304-3835(99)00176-7
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Surgery publications

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