Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/10196
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Type: Journal article
Title: A comparison of subcutaneous morphine and Fentanyl in hospice cancer patients
Author: Hunt, R.
Fazekas, B.
Thorne, D.
Brooksbank, M.
Citation: Journal of Pain and Symptom Management, 1999; 18(2):111-119
Publisher: Dept. of Anesthesiology, University of Wisconsin
Issue Date: 1999
ISSN: 0885-3924
1873-6513
Statement of
Responsibility: 
Hunt, Roger ; Fazekas, Belinda ; Thorne, David ; Brooksbank, Mary
Abstract: This study compares subcutaneous (s.c.) morphine and fentanyl with respect to pain control and side effects using a 6-day randomized, double-blind, cross-over design. Results were obtained from 23 patients (12 males and 11 females: mean age of 70.5 years) who could tolerate morphine. Thirteen patients were randomized to receive morphine for the first 3 days followed by fentanyl; 10 received fentanyl first followed by morphine. There were no significant differences in the scores for pain between the two drugs, suggesting that fentanyl is equally efficacious and the conversion ratio of morphine 10 mg: fentanyl 150 micrograms is appropriate. Patients had more frequent bowel movements during days 4-6 while on the fentanyl arm [t-test, df (22), P = 0.015]. Other measures for nausea, delirium, and cognitive function showed no differences between the two drugs. This study highlights the need to further assess the role of various opioids in hospice patients, and emphasizes the requirement for sensitive and simple cognitive tests in this population.
Keywords: Humans; Neoplasms; Pain; Morphine; Fentanyl; Analgesics, Opioid; Hospice Care; Injections, Subcutaneous; Aged; Aged, 80 and over; Middle Aged; Female; Male
RMID: 0030004598
DOI: 10.1016/S0885-3924(99)00051-2
Appears in Collections:Surgery publications

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