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Type: Journal article
Title: Mitogenic whey extract stimulates wound repair activity in vitro and promotes healing of rat incisional wounds
Author: Rayner, T.
Cowin, A.
Gray, J.
Cooter, R.
Harries, R.
Regester, G.
Smithers, G.
Goddard, C.
Belford, D.
Citation: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2000; 278(6 47-6):R1651-R1660
Publisher: Amer Physiological Soc
Issue Date: 2000
ISSN: 0363-6119
Statement of
Timothy E. Rayner, Allison J. Cowin, J. Gray Robertson, Rodney D. Cooter, Richard C. Harries, Geoffrey O. Regester, Geoffrey W. Smithers, Chris Goddard, and David A. Belford
Abstract: The ability of single growth factors to promote healing of normal and compromised wounds has been well described, but wound healing is a process requiring the coordinated action of multiple growth factors. Only the synergistic effect on wound healing of combinations containing at most two individual growth factors has been reported. We sought to assess the ability of a novel milk-derived growth factor-enriched preparation ┬┐mitogenic bovine whey extract (MBWE), which contains six known growth factors, to promote repair processes in organotypic in vitro models and incisional wounds in vivo. MBWE stimulated the contraction of fibroblast-populated collagen lattices in a dose-dependent fashion and promoted the closure of excisional wounds in embryonic day 17 fetal rat skin. Application of MBWE increased incisional wound strength in normal animals on days 3, 5, 7, and 10 and reversed the decrease in wound strength observed following steroid treatment. Wound histology showed increased fibroblast numbers in wounds from normal and steroid-compromised animals. These data suggest the mixture of factors present in bovine milk exerts a direct action on the cells of cutaneous wound repair to enhance both normal and compromised healing.
Keywords: 3T3 Cells
Mice, Inbred BALB C
Rats, Sprague-Dawley
Milk Proteins
Organ Culture Techniques
Wound Healing
Dose-Response Relationship, Drug
Dermatologic Surgical Procedures
DOI: 10.1152/ajpregu.2000.278.6.r1651
Appears in Collections:Aurora harvest 2
Surgery publications

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