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https://hdl.handle.net/2440/105537
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dc.contributor.author | Selth, L. | - |
dc.contributor.author | Das, R. | - |
dc.contributor.author | Townley, S. | - |
dc.contributor.author | Coutinho, I. | - |
dc.contributor.author | Hanson, A. | - |
dc.contributor.author | Centenera, M. | - |
dc.contributor.author | Stylianou, N. | - |
dc.contributor.author | Sweeney, K. | - |
dc.contributor.author | Soekmadji, C. | - |
dc.contributor.author | Jovanovic, L. | - |
dc.contributor.author | Nelson, C. | - |
dc.contributor.author | Zoubeidi, A. | - |
dc.contributor.author | Butler, L. | - |
dc.contributor.author | Goodall, G. | - |
dc.contributor.author | Hollier, B. | - |
dc.contributor.author | Gregory, P. | - |
dc.contributor.author | Tilley, W. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Oncogene, 2017; 36(1):24-34 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | http://hdl.handle.net/2440/105537 | - |
dc.description.abstract | MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely correlated with epithelial–mesenchymal transition signatures (EMT) in clinical samples and can drive mesenchymal–epithelial transition (MET) in model systems. Indeed, miR-375 potently inhibited invasion and migration of multiple prostate cancer lines. The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer. Knockdown of YAP1 phenocopied miR-375 overexpression, and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375. Furthermore, transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor, ZEB1. Analysis of multiple patient cohorts provided evidence for this ZEB1-miR-375-YAP1 regulatory circuit in clinical samples. Despite its anti-invasive and anti-EMT capacities, plasma miR-375 was found to be correlated with circulating tumor cells in men with metastatic disease. Collectively, this study provides new insight into the function of miR-375 in prostate cancer, and more broadly identifies a novel pathway controlling epithelial plasticity and tumor cell invasion in this disease. | - |
dc.description.statementofresponsibility | LA Selth, R Das, SL Townley, I Coutinho, AR Hanson, MM Centenera, N Stylianou, K Sweeney, C Soekmadji, L Jovanovic, CC Nelson, A Zoubeidi, LM Butler, GJ Goodall, BG Hollier, PA Gregory, and WD Tilley | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved | - |
dc.source.uri | http://dx.doi.org/10.1038/onc.2016.185 | - |
dc.subject | Epithelium | - |
dc.subject | Cell Line, Tumor | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Prostatic Neoplasms | - |
dc.subject | Adaptor Proteins, Signal Transducing | - |
dc.subject | Phosphoproteins | - |
dc.subject | Transcription Factors | - |
dc.subject | MicroRNAs | - |
dc.subject | 3' Untranslated Regions | - |
dc.subject | Signal Transduction | - |
dc.subject | Gene Expression | - |
dc.subject | Gene Expression Regulation, Neoplastic | - |
dc.subject | RNA Interference | - |
dc.subject | Phenotype | - |
dc.subject | Male | - |
dc.subject | Proto-Oncogene Proteins c-met | - |
dc.subject | Neoplastic Cells, Circulating | - |
dc.subject | Epithelial-Mesenchymal Transition | - |
dc.subject | Biomarkers | - |
dc.subject | Zinc Finger E-box-Binding Homeobox 1 | - |
dc.subject | YAP-Signaling Proteins | - |
dc.title | A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/onc.2016.185 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1083961 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selth, L. [0000-0002-4686-1418] | - |
dc.identifier.orcid | Centenera, M. [0000-0002-2206-0632] | - |
dc.identifier.orcid | Butler, L. [0000-0003-2698-3220] | - |
dc.identifier.orcid | Goodall, G. [0000-0003-1294-0692] | - |
dc.identifier.orcid | Gregory, P. [0000-0002-0999-0632] | - |
dc.identifier.orcid | Tilley, W. [0000-0003-1893-2626] | - |
Appears in Collections: | Aurora harvest 3 Medical Education Unit publications |
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