Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: The effect of immune enhancement and suppression on the development of laparoscopic port site metastases
Author: Neuhaus, S.
Watson, D.
Ellis, T.
Rofe, A.
Jamieson, G.
Citation: Surgical Endoscopy: surgical and interventional techniques, 2000; 14(5):439-443
Publisher: Springer
Issue Date: 2000
ISSN: 0930-2794
Abstract: <h4>Background</h4>Recent clinical case reports and experimental studies have suggested that laparoscopic cancer surgery is associated with an increased risk of tumor spread to abdominal wall wounds. While the etiology of this problem was initially believed to be related to mechanical contamination of wounds, it is now recognized that there are other contributory factors, including disturbed immune function within the peritoneal cavity. To investigate this question further, we evaluated the effect of immune modulation within an established laparoscopic cancer model.<h4>Methods</h4>Eighteen immune-competent syngeneic rats underwent modulation of their immune system, followed 18 h later by laparoscopy with the introduction of a suspension of adenocarcinoma cells into the peritoneal cavity. Rats were randomly allocated to receive either systemic cyclosporin (immune suppressor), intraperitoneal endotoxin (immune enhancer), or no agent (controls). Seven days later, all rats were killed and their peritoneal cavity was inspected for tumor implantation and port site metastases.<h4>Results</h4>Cyclosporin did not influence the study outcome, but tumor growth (p = 0.008) and port site metastases (p < 0.0001) were less common following the administration of intraperitoneal endotoxin.<h4>Conclusion</h4>The results of this study suggest that the immune system plays a role in the genesis of port site metastases. A preventive role for endotoxin in patients undergoing laparoscopic cancer surgery, however, remains speculative.
Keywords: Abdominal Muscles
Rats, Inbred Strains
Peritoneal Neoplasms
Neoplasm Metastasis
Neoplasm Seeding
Disease Models, Animal
Immunosuppressive Agents
Adjuvants, Immunologic
DOI: 10.1007/s004640000157
Published version:
Appears in Collections:Aurora harvest 7
Surgery publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.