Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111488
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Type: Journal article
Title: Circulating biomarkers are not associated with endoleaks after endovascular repair of abdominal aortic aneurysms
Author: Moxon, J.
Ng, E.
Lazzaroni, S.
Boult, M.
Velu, R.
Fitridge, R.
Golledge, J.
Citation: Journal of Vascular Surgery, 2018; 67(3):770-777
Publisher: Elsevier
Issue Date: 2018
ISSN: 0741-5214
1097-6809
Statement of
Responsibility: 
Joseph V. Moxon, Eugene Ng, Sharon M. Lazzaroni, Margaret Boult, Ramesh Velu, Robert A. Fitridge, and Jonathan Golledge
Abstract: Objective: Endoleak is a common complication of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA) but can be detected only through prolonged follow-up with repeated aortic imaging. This study examined the potential for circulating matrix metalloproteinase 9 (MMP9), osteoprotegerin (OPG), D-dimer, homocysteine (HCY), and C-reactive protein (CRP) to act as diagnostic markers for endoleak in AAA patients undergoing elective EVAR. Methods: Linear mixed-effects models were constructed to assess differences in AAA diameter after EVAR between groups of patients who did and did not develop endoleak during follow-up, adjusting for potential confounders. Circulating MMP9, OPG, D-dimer, HCY, and CRP concentrations were measured in preoperative and postoperative plasma samples. The association of these markers with endoleak diagnosis was assessed using linear mixed effects adjusted as before. The potential for each marker to diagnose endoleak was assessed using receiver operating characteristic curves. Results: Seventy-five patients were included in the study, 24 of whom developed an endoleak during follow-up. Patients with an endoleak had significantly larger AAA sac diameters than those who did not have an endoleak. None of the assessed markers showed a significant association with endoleak. This was confirmed through receiver operating characteristic curve analyses indicating poor diagnostic ability for all markers. Conclusions: Circulating concentrations of MMP9, OPG, D-dimer, HCY, and CRP were not associated with endoleak in patients undergoing EVAR in this study.
Keywords: Humans; Aortic Aneurysm, Abdominal; Homocysteine; C-Reactive Protein; Fibrin Fibrinogen Degradation Products; Aortography; Treatment Outcome; Blood Vessel Prosthesis Implantation; Registries; Area Under Curve; Linear Models; Risk Factors; Prospective Studies; Predictive Value of Tests; ROC Curve; Aged; Aged, 80 and over; Australia; Female; Male; Matrix Metalloproteinase 9; Osteoprotegerin; Endovascular Procedures; Endoleak; Biomarkers; Computed Tomography Angiography
Rights: Crown Copyright © 2017 Published by Elsevier Inc. on behalf of the Society for Vascular Surgery. All rights reserved.
RMID: 0030074690
DOI: 10.1016/j.jvs.2017.06.090
Grant ID: http://purl.org/au-research/grants/nhmrc/1022752
http://purl.org/au-research/grants/nhmrc/1000967
http://purl.org/au-research/grants/nhmrc/1117061
Appears in Collections:Surgery publications

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