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https://hdl.handle.net/2440/113253
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dc.contributor.author | Parkinson, L. | - |
dc.contributor.author | Magin, P. | - |
dc.contributor.author | Thomson, A. | - |
dc.contributor.author | Byles, J. | - |
dc.contributor.author | Caughey, G. | - |
dc.contributor.author | Etherton-Beer, C. | - |
dc.contributor.author | Gnjidic, D. | - |
dc.contributor.author | Hilmer, S. | - |
dc.contributor.author | Lo, T. | - |
dc.contributor.author | McCowan, C. | - |
dc.contributor.author | Moorin, R. | - |
dc.contributor.author | Pond, C. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Medical Journal of Australia, 2015; 202(2):91-95 | - |
dc.identifier.issn | 0025-729X | - |
dc.identifier.issn | 1326-5377 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113253 | - |
dc.description.abstract | OBJECTIVES: To identify medicines contributing to and describe predictors of anticholinergic burden among community-dwelling older Australian women. DESIGN, SETTING AND PARTICIPANTS: Retrospective longitudinal analysis of data from the Australian Longitudinal Study on Women's Health linked to Pharmaceutical Benefits Scheme medicines data from 1 January 2008 to 30 December 2010; for 3694 women born in 1921-1926. MAIN OUTCOME MEASURES: Anticholinergic burden calculated from Anticholinergic Drug Scale (ADS) scores derived from ADS levels (0 to 3) for all medicines used by each woman, summed over each 6-month period (semester), medicines commonly used by women with high semester ADS scores (defined as 75th percentile of scores). RESULTS: 1126 women (59.9%) used at least one medicine with anticholinergic properties. The median ADS score was 4 or 5 across all semesters. Most anticholinergic medicines used by women who had a high anticholinergic burden (ADS score, ≥ 9) had a low anticholinergic potency (ADS level 1). Increasing age, cardiovascular disease, and number of other medicines used were predictive of a higher anticholinergic burden. CONCLUSIONS: A high anticholinergic medicines burden in this group was driven by the use of multiple medicines with lower anticholinergic potency rather than the use of medicines with higher potency. This is a novel and important finding for clinical practice as doctors would readily identify the risk of a high anticholinergic burden for patients using high potency medicines, but may be less likely to identify this risk for users of multiple medicines with low anticholinergic potency. | - |
dc.description.statementofresponsibility | Lynne Parkinson, Parker J Magin, Allison Thomson, Julie E Byles, Gillian E Caughey, Christopher Etherton-Beer, Danijela Gnjidic, Sarah N Hilmer, Thomas King Tong Lo, Colin McCowan, Rachael Moorin, C Dimity Pond | - |
dc.language.iso | en | - |
dc.publisher | Australasian Medical Publishing Company | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.5694/mja14.00336 | - |
dc.subject | Cholinergic Antagonists | - |
dc.title | Anticholinergic burden in older women: not seeing the wood for the trees? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.5694/mja14.00336 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Caughey, G. [0000-0003-1192-4121] | - |
Appears in Collections: | Aurora harvest 3 Pharmacology publications |
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