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Type: Conference paper
Title: Measurements of vitamin B12 in human blood serum using resonance Raman spectroscopy
Author: Tsiminis, G.
Schartner, E.
Brooks, J.
Hutchinson, M.
Citation: Proceedings of SPIE, 2016 / Hutchinson, M., Goldys, E. (ed./s), vol.10013, pp.100130M-1-100130M-4
Publisher: SPIE
Issue Date: 2016
Series/Report no.: Proceedings of SPIE
ISBN: 9781510604346
ISSN: 0277-786X
Conference Name: SPIE BioPhotonics Australasia (17 Oct 2016 - 19 Oct 2016 : Adelaide, Australia)
Editor: Hutchinson, M.
Goldys, E.
Statement of
G. Tsiminis, E. P. Schartner, J. L. Brooks, M. R. Hutchinson
Abstract: Vitamin B12 (cobalamin and its derivatives) deficiency has been identified as a potential modifiable risk factor for dementia and Alzheimer’s disease. Chronic deficiency of vitamin B12 has been significantly associated with an increased risk of cognitive decline. An effective and efficient method for measuring vitamin B12 concentration in human blood would enable ongoing tracking and assessment of this potential modifiable risk factor. In this work we present an optical sensor based on resonance Raman spectroscopy for rapid measurements of vitamin B12 in human blood serum. The measurement takes less than a minute and requires minimum preparation (centrifuging) of the collected blood samples.
Keywords: Raman spectroscopy; vitamin B12; optical spectroscopy; dementia; Alzheimer’s disease; cognitive decline
Rights: © 2016 SPIE
DOI: 10.1117/12.2244620
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