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https://hdl.handle.net/2440/117830
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dc.contributor.author | Zhang, R. | - |
dc.contributor.author | Liang, L. | - |
dc.contributor.author | Meng, Q. | - |
dc.contributor.author | Zhao, J. | - |
dc.contributor.author | Ta, H.T. | - |
dc.contributor.author | Li, L. | - |
dc.contributor.author | Zhang, Z. | - |
dc.contributor.author | Sultanbawa, Y. | - |
dc.contributor.author | Xu, Z.P. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Small, 2019; 15(2):1803712-1-1803712-11 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.issn | 1613-6829 | - |
dc.identifier.uri | http://hdl.handle.net/2440/117830 | - |
dc.description.abstract | Responsive nanoprobes play an important role in bioassay and bioimaging, early diagnosis of diseases and treatment monitoring. Herein, a upconversional nanoparticle (UCNP)-based nanoprobe, Ru@UCNPs, for specific sensing and imaging of hypochlorous acid (HOCl) is reported. This Ru@UCNP nanoprobe consists of two functional components,, i.e., NaYF₄ :Yb, Tm UCNPs that can convert near infrared light-to-visible light as the energy donor, and a HOCl-responsive ruthenium(II) complex [Ru(bpy)₂ (DNCH-bpy)](PF₆)₂ (Ru-DNPH) as the energy acceptor and also the upconversion luminescence (UCL) quencher. Within this luminescence resonance energy transfer nanoprobe system, the UCL OFF-ON emission is triggered specifically by HOCl. This triggering reaction enables the detection of HOCl in aqueous solution and biological systems. As an example of applications, the Ru@UCNPs nanoprobe is loaded onto test papers for semiquantitative HOCl detection without any interference from the background fluorescence. The application of Ru@UCNPs for background-free detection and visualization of HOCl in cells and mice is successfully demonstrated. This research has thus shown that Ru@UCNPs is a selective HOCl-responsive nanoprobe, providing a new way to detect HOCl and a new strategy to develop novel nanoprobes for in situ detection of various biomarkers in cells and early disgnosis of animal diseases. | - |
dc.description.statementofresponsibility | Run Zhang, Liuen Liang, Qingtao Meng, Jiangbo Zhao, Hang T. Ta, Li Li, Zhiqiang Zhang, Yasmina Sultanbawa and Zhi Ping Xu | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/smll.201803712 | - |
dc.subject | Bioassay and imaging; luminescence resonance energy transfer; nanoprobes; paper-based test strips; selective HOCl detection and imaging | - |
dc.title | Responsive upconversion nanoprobe for background-free hypochlorous acid detection and bioimaging | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/smll.201803712 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP170104643 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DE170100092 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1125794 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zhao, J. [0000-0002-5883-6017] | - |
Appears in Collections: | Aurora harvest 8 IPAS publications |
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