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Type: Journal article
Title: Ventilatory decline after hypoxia and hypercapnia is not different between healthy young men and women
Author: Jordan, A.
Catcheside, P.
Orr, R.
O'Donoghue, F.
Saunders, N.
McEvoy, R.
Citation: Journal of Applied Physiology, 2000; 88(1):3-9
Publisher: Amer Physiological Soc
Issue Date: 2000
ISSN: 8750-7587
Abstract: The gradual decay in ventilation after removal of a respiratory stimulus has been proposed to protect against cyclic breathing disorders such as obstructive sleep apnea (OSA). The male predominance of OSA, and the increased incidence of OSA in women after menopause, indicates that the respiratory-stimulating effect of progesterone may provide protection against OSA by altering the rate of poststimulus ventilatory decline (PSVD). It was therefore hypothesized that PSVD is longer in premenopausal women than in men and is longer in the luteal menstrual phase compared with the follicular phase. PSVD was measured in 12 men and in 11 women at both their luteal and follicular phases, after cessation of isocapnic hypoxia and normoxic hypercapnia. PSVD was compared between genders and between women in the luteal and follicular phases by repeated-measures ANOVA. There were no significant differences in PSVD between any of the groups after either respiratory stimulus. This suggests that the higher occurrence of OSA in men does not reflect an underlying gender difference in PSVD and implies the increased prevalence of OSA in women after menopause is not representative of an effect of progesterone on PSVD.
Keywords: Lung
Sleep Apnea, Obstructive
Carbon Dioxide
Pulmonary Ventilation
Body Mass Index
Follicular Phase
Luteal Phase
Sex Characteristics
Time Factors
Rights: Copyright © 2000 the American Physiological Society
DOI: 10.1152/jappl.2000.88.1.3
Appears in Collections:Aurora harvest 7
Physiology publications

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