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Type: Journal article
Title: Differential effects of placental restriction on IDF-II, ACTH receptor and steroidogenic enzyme mRNA levels in the foetal sheep adrenal
Author: Ross, J.
Phillips, I.
Simonetta, G.
Owens, J.
Robinson, J.
McMillen, I.
Citation: Journal of Neuroendocrinology, 2000; 12(1):79-85
Publisher: Blackwell Science Ltd
Issue Date: 2000
ISSN: 0953-8194
Abstract: We have investigated the effects of restriction of placental growth on foetal adrenal growth and adrenal expression of mRNAs for Insulin-like Growth Factor II (IGF-II), the IGF binding protein IGFBP-2, Steroidogenic Factor 1 (SF-1) and adrenocorticotrophic hormone (ACTH) receptor (ACTH-R) and the steroidogenic cytochrome P-450 enzymes: cholesterol side chain cleavage (CYP11A1), 17alpha-hydroxylase (CYP17) and 21-hydroxylase (CYP21A1); and 3beta-hydroxysteroid dehydrogenase/Delta5Delta4 isomerase (3betaHSD). Endometrial caruncles were removed from non-pregnant ewes before mating (placental restriction group; PR). The total adrenal: foetal weight ratio was higher in PR (n=6 foetuses) than in control foetuses (n=6 foetuses). There was no difference in plasma ACTH concentrations between the PR and control foetuses between 130 and 140 days gestation. Adrenal IGF-II mRNA levels were lower (P<0.05) in the PR group, however, adrenal IGFBP-2 mRNA levels were not different between the PR and control groups. Adrenal ACTH-R mRNA levels were also lower whilst CYP11A1 mRNA levels were increased (P<0.005) in the PR group. We conclude that foetal adrenal growth and steroidogenesis are stimulated as a consequence of foetal growth restriction and that factors other than ACTH are important in foetal adrenal activation during chronic, sustained hypoxaemia.
Keywords: Adrenal Glands
Multienzyme Complexes
Cytochrome P-450 Enzyme System
Cholesterol Side-Chain Cleavage Enzyme
Steroid 17-alpha-Hydroxylase
Steroid 21-Hydroxylase
Steroid Isomerases
Progesterone Reductase
Insulin-Like Growth Factor II
Receptors, Corticotropin
RNA, Messenger
Organ Size
Transcription, Genetic
Reference Values
DOI: 10.1046/j.1365-2826.2000.00429.x
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