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|Title:||Time course of induction of increased human motor cortex excitability by nerve stimulation|
|Citation:||Neuroreport, 2002; 13(10):1271-1273|
|Publisher:||Lippincott Williams & Wilkins|
|McKay, Darrin; Brooker, Raylene; Giacomin, Paul; Ridding, Michael; Miles, Timothy|
|Abstract:||Manipulation of afferent input induces changes in the excitability and organisation of human corticomotor representations. These changes are generally short lived, although can be prolonged by repetition. Here, we charted the time-course of the change of motor cortex excitability induced by electrical stimulation of radial and ulnar nerves. Corticomotor excitability was evaluated by measuring the amplitude of the motor evoked potentials in the first dorsal interosseous muscle by transcranial magnetic stimulation of the optimal cortical area. Measurements were carried out before the start of peripheral nerve stimulation, and then during the peripheral nerve stimulation at 15 min intervals over a period of 2 h. The amplitudes of the motor evoked potentials significantly increased during the 2 h period of peripheral nerve stimulation. Cortical excitability peaked after about 45-60 min stimulation. These clear-cut changes in cortical excitability following peripheral nerve stimulation may reveal some of the mechanisms underlying motor learning and cortical plasticity.|
|Keywords:||Motor Cortex; Radial Nerve; Ulnar Nerve; Humans; Electric Stimulation; Evoked Potentials, Motor; Neuronal Plasticity; Magnetics; Adult; Female; Male|
|Description:||Copyright © 2002 Lippincott Williams & Wilkins, Inc.|
|Appears in Collections:||Physiology publications|
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