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Type: Journal article
Title: Fetal growth restriction: adaptations and consequences
Author: McMillen, I.
Adams, M.
Ross, J.
Coulter, C.
Simonetta, G.
Owens, J.
Robinson, J.
Edwards, L.
Citation: Reproduction, 2001; 122(2):195-204
Publisher: Journals of Reproduction Fertility Ltd
Issue Date: 2001
ISSN: 1470-1626
Statement of
I.C. McMillen, M.B. Adams, J.T. Ross, C.L. Coulter, G. Simonetta, J.A. Owens, J.S. Robinson and L.J. Edwards
Abstract: A range of pathophysiological factors can result in a perturbation or restriction of fetal growth, and the cardiovascular, neuroendocrine and metabolic adaptations of the fetus to these stimuli will depend on their nature, timing and intensity. The critical importance of these physiological adaptations for both immediate survival and long-term health outcomes has provided an impetus for experimental studies of the nature and consequences of specific fetal adaptations to a poor intrauterine environment. This review summarizes data from recent studies that have focused on the responses of the fetal cardiovascular, sympathoadrenal, hypothalamo-pituitary-adrenal and renin-angiotensin systems to experimental restriction of placental function in the sheep and discusses the consequences of these adaptations for fetal, neonatal and adult health.
Keywords: Adrenal Glands; Pituitary Gland; Cardiovascular System; Hypothalamus; Sympathetic Nervous System; Placenta; Animals; Humans; Fetal Growth Retardation; Glucocorticoids; Adaptation, Physiological; Renin-Angiotensin System; Pregnancy; Female
Description: Copyright © 2001 Society for Reproduction and Fertility
RMID: 0020012177
DOI: 10.1530/rep.0.1220195
Appears in Collections:Physiology publications

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