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Type: Journal article
Title: Phosphorylation and signal transduction pathways in translational control
Author: Proud, C.
Citation: Cold Spring Harbor perspectives in biology, 2019; 11(7):a033050-1-a033050-22
Publisher: Cold Spring Harbor Laboratory Press
Issue Date: 2019
ISSN: 1943-0264
Statement of
Christopher G. Proud
Abstract: Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is regulated by extracellular stimuli such as hormones and by the levels of certain nutrients within cells. This control involves several well-understood signaling pathways and protein kinases, which regulate the phosphorylation of proteins that control the translational machinery. These pathways include the mechanistic target of rapamycin complex 1 (mTORC1), its downstream effectors, and the mitogen-activated protein (MAP) kinase (extracellular ligand-regulated kinase [ERK]) signaling pathway. This review describes the regulatory mechanisms that control translation initiation and elongation factors, in particular the effects of phosphorylation on their interactions or activities. It also discusses current knowledge concerning the impact of these control systems on the translation of specific mRNAs or subsets of mRNAs, both in physiological processes and in diseases such as cancer.
Keywords: Mitogen-Activated Protein Kinase Kinases
Signal Transduction
Protein Biosynthesis
Gene Expression Regulation
Mechanistic Target of Rapamycin Complex 1
Rights: © 2019 Cold Spring Harbor Laboratory Press; all rights reserved
DOI: 10.1101/cshperspect.a033050
Appears in Collections:Aurora harvest 8
Molecular and Biomedical Science publications

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