Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Phosphorylation and signal transduction pathways in translational control|
|Citation:||Cold Spring Harbor Perspectives in Biology, 2019; 11(7):a033050-1-a033050-22|
|Publisher:||Cold Spring Harbor Laboratory Press|
|Christopher G. Proud|
|Abstract:||Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is regulated by extracellular stimuli such as hormones and by the levels of certain nutrients within cells. This control involves several well-understood signaling pathways and protein kinases, which regulate the phosphorylation of proteins that control the translational machinery. These pathways include the mechanistic target of rapamycin complex 1 (mTORC1), its downstream effectors, and the mitogen-activated protein (MAP) kinase (extracellular ligand-regulated kinase [ERK]) signaling pathway. This review describes the regulatory mechanisms that control translation initiation and elongation factors, in particular the effects of phosphorylation on their interactions or activities. It also discusses current knowledge concerning the impact of these control systems on the translation of specific mRNAs or subsets of mRNAs, both in physiological processes and in diseases such as cancer.|
|Keywords:||Mitogen-Activated Protein Kinase Kinases; Signal Transduction; Protein Biosynthesis; Gene Expression Regulation; Phosphorylation; Mechanistic Target of Rapamycin Complex 1|
|Rights:||© 2019 Cold Spring Harbor Laboratory Press; all rights reserved|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.