Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/122038
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Type: Journal article
Title: Cognitive deficits in the THINC-integrated tool (THINC-it) are associated with psychosocial dysfunction in patients with major depressive disorder
Author: Knight, M.
Fourrier, C.
Lyrtzis, E.
Aboustate, N.
Sampson, E.
Hori, H.
Mills, N.
Baune, B.
Citation: Journal of Clinical Psychiatry, 2019; 80(1):18m12472-1-18m12472-8
Publisher: Physicians Postgraduate Press, Inc.
Issue Date: 2019
ISSN: 0160-6689
1555-2101
Statement of
Responsibility: 
Matthew J. Knight, Célia Fourrier, Ellen Lyrtzis, Natalie Aboustate, Emma Sampson, Hikaru Hori, Natalie T. Mills, and Bernhard T. Baune
Abstract: Objective: To evaluate the extent to which cognitive measures in the recently developed THINC-integrated tool (THINC-it) are associated with global and domain specific psychosocial disability in patients with current and remitted major depressive disorder (MDD). Methods: Cross-sectional data (N = 127) were obtained from participants with current (n = 105) or remitted (n = 22) MDD who completed the THINC-it between July 2014 and June 2018. Major depressive disorder was diagnostically assessed with DSM-IV and DSM-5 criteria. The THINC-it includes 4 objective cognitive tests: the Spotter (ie, Choice Reaction Time), Symbol Check (ie, n-back), CodeBreaker (ie, Digit Symbol Substitution), and Trails (ie, Trail Making Test part B), as well as a measure of self-perceived cognitive deficits, the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D). Psychosocial dysfunction was assessed with the Functioning Assessment Short Test. Results: The whole group analysis (ie, lifetime MDD) indicated that poor objective cognitive performance on the CodeBreaker (β = 0.346, P = .002) and Trails tasks (β = 0.232, P = .017) and greater self-reported cognitive deficits on the PDQ-5-D (β = 0.596, P < .001) were associated with more severe global psychosocial disability. In addition, performance on the CodeBreaker and Trails tasks showed dissociable relationships with specific psychosocial deficits (eg, occupational functioning, daily autonomy). The relationship between cognitive and psychosocial deficits was stronger in participants with current compared to remitted MDD. Conclusions: Cognitive deficits identified by the THINC-it are associated with global and specific psychosocial deficits, highlighting the clinical value and utility of the THINC-it as a cognitive screening instrument in patients with MDD.
Keywords: Major Depressive Disorder
Rights: © Copyright 2018 Physicians Postgraduate Press, Inc.
RMID: 0030105684
DOI: 10.4088/JCP.18m12472
Appears in Collections:Psychiatry publications

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