Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124218
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| Type: | Journal article |
| Title: | Hidden secrets of sigma54 promoters revealed |
| Author: | Hao, N. Shearwin, K.E. |
| Citation: | Trends in Biochemical Sciences, 2017; 42(12):931-932 |
| Publisher: | Elsevier |
| Issue Date: | 2017 |
| ISSN: | 0968-0004 1362-4326 |
| Statement of Responsibility: | Nan Hao and Keith E. Shearwin |
| Abstract: | Bacterial sigma54 (σ⁵⁴) promoters are the DNA-binding motif for σ⁵⁴-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ⁵⁴ promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation. |
| Keywords: | DNA-Directed RNA Polymerases |
| Rights: | © 2017 Elsevier Ltd. All rights reserved. |
| DOI: | 10.1016/j.tibs.2017.10.005 |
| Published version: | http://dx.doi.org/10.1016/j.tibs.2017.10.005 |
| Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
Files in This Item:
| File | Description | Size | Format | |
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| hdl_124218.pdf | Submitted version | 576.42 kB | Adobe PDF | View/Open |
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