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Type: Journal article
Title: Hidden secrets of sigma54 promoters revealed
Author: Hao, N.
Shearwin, K.
Citation: Trends in Biochemical Sciences, 2017; 42(12):931-932
Publisher: Elsevier
Issue Date: 2017
ISSN: 0968-0004
Statement of
Nan Hao and Keith E. Shearwin
Abstract: Bacterial sigma54 (σ⁵⁴) promoters are the DNA-binding motif for σ⁵⁴-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ⁵⁴ promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation.
Keywords: DNA-Directed RNA Polymerases
Rights: © 2017 Elsevier Ltd. All rights reserved.
RMID: 0030077688
DOI: 10.1016/j.tibs.2017.10.005
Appears in Collections:Molecular and Biomedical Science publications

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